【佳學(xué)基因檢測】p53在胃癌中的表達(dá)與預(yù)后
基因檢測的費(fèi)用是多少詳解
討化腫瘤分子診斷與基因分析《腫瘤靶向藥物選擇的基因突變標(biāo)準(zhǔn)》《Int J Cancer》在. 1992 Apr 1;50(6):859-62.發(fā)表了一篇題目為《p53在胃癌中的表達(dá)與預(yù)后》癌癥致病基因深度研究文章。該研究由H M Martin , M I Filipe, R W Morris, D P Lane, F Silvestre等完成。評估和介紹了P53A基因檢測的專業(yè)性和價值開發(fā)方式方法,進(jìn)一步強(qiáng)調(diào)對關(guān)鍵基因進(jìn)行深度檢測的重要性。
腫瘤遺傳力大小分析研究內(nèi)容關(guān)鍵詞:
P53基因突變,消化科,生存期,中位生存率
腫瘤靶向治療基因檢測臨床應(yīng)用結(jié)果
腫瘤科、消化科的腫瘤基因解碼表明,基因檢測已在許多惡性腫瘤中發(fā)現(xiàn) p53 基因異常。據(jù)腫瘤致病基因鑒定基因解碼,超過一半的結(jié)直腸癌、肺癌、乳腺癌和肝細(xì)胞癌病例存在異常。正常基因充當(dāng)隱性癌基因,而突變將表觀功能改變?yōu)轱@性癌基因的功能。在這項研究中,使用多克隆抗 p53 抗體 (CM-I),將 3 層免疫過氧化物酶技術(shù)應(yīng)用于來自 125 例胃癌的常規(guī)固定和石蠟包埋的組織切片。P53的腫瘤致病性研究發(fā)現(xiàn)這些癌中有 57% 表達(dá)高水平的 p53 蛋白(陽性核染色)。生存分析顯示腫瘤的 p53 狀態(tài)與診斷后患者的生存時間之間存在密切關(guān)聯(lián)(p = 0.02,Mantel-Cox 檢驗);死亡的優(yōu)勢比,2.09(95% 置信區(qū)間 1.02 至 4.25)。表達(dá) p53 的腫瘤患者的 5 年生存率為 24%,而非表達(dá) p53 的腫瘤患者的 5 年生存率為 56%(中位生存時間分別為 13 個月和 102 個月)。
腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國際數(shù)據(jù)庫描述:
Abnormalities of the p53 gene have been identified in many malignancies, with reports of aberration in over half of colorectal, lung, breast and hepatocellular carcinoma cases. The normal gene acts as a recessive oncogene, while mutations change the apparent function to that of a dominant oncogene. In this investigation a 3-layered immunoperoxidase technique was applied to routinely fixed and paraffin-embedded tissue sections from 125 gastric carcinomas, using a polyclonal anti-p53 antibody (CM-I). We found that 57% of these carcinomas expressed high levels of p53 protein (positive nuclear staining). Survival analysis revealed a strong association between p53 status of the tumour and patient survival time after diagnosis (p = 0.02, Mantel-Cox Test); odds ratio of death, 2.09 (95% confidence interval 1.02 to 4.25). The 5-year survival of patients with p53-expressing tumours was 24%, compared with 56% for those non-p53-expressing tumours (the median survival times were 13 and 102 months, respectively).
(責(zé)任編輯:佳學(xué)基因)