【佳學(xué)基因檢測(cè)】家族性腦腫瘤的基因解碼和臨床基因檢測(cè)應(yīng)用

基因檢測(cè)要多少錢(qián)—答案

在高峰論壇中了解《Brain Nerve》在 2012 May;64(5):557-64發(fā)表了一篇題目為《家族性腦腫瘤的基礎(chǔ)科學(xué)和臨床方面》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Hiroshi Kanno 等完成。進(jìn)一步揭示了神經(jīng)腫瘤的基因位點(diǎn)及基因所編碼的蛋白質(zhì)的作用，進(jìn)一步強(qiáng)調(diào)了基因檢測(cè)有腦腫瘤的正確治療中的作用。

腫瘤靶向藥物及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

家族性,腦腫瘤,神經(jīng)纖維瘤病,結(jié)節(jié)性硬化癥,多發(fā)性?xún)?nèi)分泌瘤

腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

家族性腦腫瘤綜合征包括神經(jīng)纖維瘤病 1、神經(jīng)纖維瘤病 2、結(jié)節(jié)性硬化癥、von Hippel-Lindau 病和多發(fā)性?xún)?nèi)分泌瘤 1 型，它們是遺傳性疾病。在這些疾病中，由于腫瘤抑制基因的改變而發(fā)展出各種腫瘤。家族性腦腫瘤大多是良性的，但也有一些是惡性的。家族性腦腫瘤綜合征的診斷依據(jù)是臨床診斷指南和 DNA 檢測(cè)。與散發(fā)性腦腫瘤不同，家族性腦腫瘤發(fā)生在多個(gè)部位,因此，單次手術(shù)往往不足以治療家族性腦腫瘤，往往需要治療其他器官的病變。對(duì)于家族性腦腫瘤，應(yīng)比散發(fā)性腦腫瘤更謹(jǐn)慎地考慮手術(shù)適應(yīng)癥。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國(guó)際數(shù)據(jù)庫(kù)描述：

Familial brain tumor syndromes include neurofibromatosis 1, neurofibromatosis 2, tuberous sclerosis, von Hippel-Lindau disease, and multiple endocrine neoplasia type 1, which are hereditary diseases. In these diseases, various tumors develop because of alterations in tumor suppressor genes. Familial brain tumors are mostly benign, but some are malignant. Familial brain tumor syndromes are diagnosed on the basis of guidelines for clinical diagnosis and by DNA test. Unlike sporadic brain tumors, familial brain tumors occur at multiple sites; therefore, a single operation is often not sufficient for treating familial brain tumors, and it is often necessary to treat lesions in other organs. Surgical indications should be considered more prudently for familial brain tumors than for sporadic brain tumors.