【佳學(xué)基因檢測】尋找癌癥易感性遺傳變異的關(guān)聯(lián)研究
腫瘤基因療法說明
開會學(xué)習(xí)《腫瘤基因突變度與預(yù)防策略的實施計劃》《Nat Rev Cancer》在?2004 Nov;4(11):850-60發(fā)表了一篇題目為《尋找癌癥易感性遺傳變異的關(guān)聯(lián)研究》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Paul D P Pharoah,?Alison M Dunning,?Bruce A J Ponder,?Douglas F Easton等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展,進一步強調(diào)了基因信息檢測與分析的重要性。
腫瘤靶向藥物及正確治療臨床研究內(nèi)容關(guān)鍵詞:
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腫瘤靶向治療基因檢測臨床應(yīng)用結(jié)果
癌癥是遺傳因素和環(huán)境因素之間復(fù)雜相互作用的結(jié)果。已知基因占癌癥遺傳力的一小部分,很可能還有許多具有適度影響的基因尚未被發(fā)現(xiàn)。遺傳關(guān)聯(lián)研究已廣泛用于尋找此類基因,但迄今為止成功有限。對基因功能和人類遺傳變異結(jié)構(gòu)的了解增加,再加上新的基因分型技術(shù),預(yù)示著通過關(guān)聯(lián)進行基因作圖的新時代。
腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國際數(shù)據(jù)庫描述:
Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
(責(zé)任編輯:佳學(xué)基因)